A simple, precise, accurate and economical UV visible spectrophotometric method has been developed for estimation of fluoxetine hydrochloride drug by AUC method. The standard and sample solutions were prepared by using double distilled water as a solvent. Quantitative determination of the drug was performed at wavelength range 220-231 nm. The linearity was established over the concentration range of 05-25 µg/ml for fluoxetine hydrochloride with correlation coefficient value of 0.9987. Precision studies showed that % relative standard deviation was within range of acceptable limits. The mean percentage recovery was found to be 98.50%. The proposed method has been validated as per ICH guidelines.
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